Looking for a Primary Care in Your Corner? Look no Further.
Your Premier Wellness & Prevention Specialists
Learn about preventative steps you can take to optimize your health to live a long, happy life as the best version of yourself
Licensed, Experienced, & Trusted Primary Care Experts
Take a Peek at a List of a Few of Our National, State, & Local Certifying & Licensing Bodies Below. We Believe Our Patient Deserve the Highest Standards of Healthcare Excellence.
Family Primary CareWe offer compassionate care for every stage of life, from childhood to retirement.
Women's WellnessWe empower women through personalized, preventative, and holistic health services.
Meet Your ProviderMeet Dr. Preston Holifield, DNP, FNP-C — dedicated to building lasting relationships through thoughtful, evidence-based care.
Referrals & AffiliatesWe proudly collaborate with trusted specialists and local partners to support comprehensive care.
Interested in Affordable Genetic Testing?
At Guardian Primary Care we believe that best way to manage one's health is to stay ahead of the game. Through the genetic testing we offer at Guardian Primary Care, we are better able to select targeted approaches for our patients & identify risk factors long before illness occurs. These tests cost as little as $0 out of pocket for qualifying patients! Click the logos above to learn more.
Patient Testimonials
"I have nothing but positive things to say about Preston and GPC! From working with him on shared patients to trusting him with the care of my family members, he is thorough and very competent. I love that he takes his time with each patient and looks for real solutions instead of pushing medicine. I highly recommend him!
- Laura M. Sanders
View/Share Testimonials"Guardian Primary Care is a fantastic addition to Cape Girardeau! The staff is professional, friendly, and truly cares about their patients. The clinic has a welcoming atmosphere, and the option for both in-person and tele-health appointments makes scheduling so convenient. It’s refreshing to see a healthcare provider that puts such an emphasis on patient comfort and accessibility. Highly recommend for anyone looking for reliable and compassionate primary care!"
- Sho R.
View/Share Testimonials"Preston is very thorough with his patients. He answers any and all questions that one may have. Highly recommend to anyone looking for a PCP that is easy to get in with and doesn’t break the bank!"
- Mercedes Stiltner
View/Share Testimonials"I’m incredibly grateful for the care of Preston Holifield! He goes above and beyond as a patient advocate, always putting his people first. He serves with kindness and excellence, ensuring every patient receives the best care possible. Despite my tight schedule, he found a way to fit me in, addressed all my needs, and even followed up to make sure everything was going as it should. I highly recommend him—he’s the Chick-fil-A of primary care!"
- Jessica S.
View/Share Testimonials"Love the practice. Extremely friendly and professional. Really takes the time to listen to their patients and very easy to work with when finding new solutions."
- Jared Mungle
View/Share Testimonials"Guardian has been a pleasant experience. Preston is very personable and professional. He actually listens and cares about your needs and doesn't feel like he trying to push you through like some places"
- Jeremy Franklin
View/Share Testimonials"We Would Love to Hear From You! Share Your Testimonial by Submitting the Contact Form with Your Review Found at the Link Below!"
- Guardian Primary Care Team
View/Share Testimonials.png){kind=spacer}
We Offer Telehealth (Click to Request Appointment)
Accepted Payment Methods
.png){kind=spacer}
.png){kind=spacer}
.svg)
