Seek Elevated Primary Care for All Ages.

Empowered in Care, Excellence in Health.

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Looking for a Primary Care in Your Corner?

Look no further.

A Peek Inside Our Practice

We Are Preferred In-Network Providers by Most Major Insurances

Full List of In-Network Insurances

Your Premier Wellness & Prevention Specialists

Learn about preventative steps you can take to optimize your health to live a long, happy life as the best version of yourself
Nutrition CounselingCancer ScreeningsRole of Holistic & Integrative CareSchool, Sports, & Employment ScreeningsExercise & ActivityWomen's WellnessRoutine Annual WellnessAND SO MUCH MORE
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Licensed, Experienced, & Trusted Primary Care Experts

Take a Peek at a List of a Few of Our National, State, & Local Certifying & Licensing Bodies Below. We Believe Our Patient Deserve the Highest Standards of Healthcare Excellence.
Family Primary Care
Women's Wellness
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We Offer Telehealth (Click to Request Appointment)
Accepted Payment Methods
Referrals & Affiliates

Interested in Affordable Genetic Testing?

Learn More About What We Offer!

At Guardian Primary Care we believe that best way to manage one's health is to stay ahead of the game. Through the genetic testing we offer at Guardian Primary Care, we are better able to select targeted approaches for our patients & identify risk factors long before illness occurs. These tests cost as little as $0 out of pocket for qualifying patients! Click the logos above to learn more.

Patient Testimonials

"Love the practice. Extremely friendly and professional. Really takes the time to listen to their patients and very easy to work with when finding new solutions."
- Jared M.
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"Guardian Primary Care is a fantastic addition to Cape Girardeau! The staff is professional, friendly, and truly cares about their patients. The clinic has a welcoming atmosphere, and the option for both in-person and tele-health appointments makes scheduling so convenient. It’s refreshing to see a healthcare provider that puts such an emphasis on patient comfort and accessibility. Highly recommend for anyone looking for reliable and compassionate primary care!"
- Sho R.
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"I’m incredibly grateful for the care of Preston Holifield! He goes above and beyond as a patient advocate, always putting his people first. He serves with kindness and excellence, ensuring every patient receives the best care possible. Despite my tight schedule, he found a way to fit me in, addressed all my needs, and even followed up to make sure everything was going as it should. I highly recommend him—he’s the Chick-fil-A of primary care!"
- Jessica S.
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"We Would Love to Hear From You! Share Your Testimonial by Submitting the Contact Form Below with Your Review!"
- Guardian Primary Care Team

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Guardian Primary Care Website

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Find Us

1420 Kurre Ln, Cape Girardeau, MO 63701
(573)-200-6390
(573)-755-0706
myprovider@guardianprimary.com
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Office Hours

Monday: 8am-5pm
Tuesday: 8am-5pm
Wednesday: 8am-5pm
Thursday: 8am-5pm
Friday: 8am-5pm
Saturday: Closed
Sunday: Closed

*By Appointment ONLY*
*Holidays May Affect These Hours*
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Established 2024
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Grand Opening January, 2025 in Cape Girardeau, MO!

Call us or Click the Link Below to Reserve Your Early Patient Registration Spot!
Early Registration Form Link

Now Open & Accepting New Patients!
‍*Virtual & In-Person Appointments Available Upon Request*

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