Looking for a Primary Care in Your Corner? Look no Further.

We Are Preferred In-Network Providers by Most Major Insurances

Full List of In-Network Insurances

A Peek Inside Our Practice

Your Premier Wellness & Prevention Specialists

Learn about preventative steps you can take to optimize your health to live a long, happy life as the best version of yourself

Nutrition Counseling Cancer Screenings Role of Holistic & Integrative Care School, Sports, & Employment Screenings Exercise & Activity Women's Wellness Routine Annual Wellness AND SO MUCH MORE

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Licensed, Experienced, & Trusted Primary Care Experts

Take a Peek at a List of a Few of Our National, State, & Local Certifying & Licensing Bodies Below. We Believe Our Patient Deserve the Highest Standards of Healthcare Excellence.

Family Primary Care

We offer compassionate care for every stage of life, from childhood to retirement.

Women's Wellness

We empower women through personalized, preventative, and holistic health services.

Meet Your Provider

Meet Nurse Practitioner Preston Holifield, DNP, FNP-C, APRN — dedicated to building lasting relationships through thoughtful, evidence-based care.

We Offer Telehealth (Click to Request Appointment)

We offer access to convenient, secure virtual visits from the comfort of your home.

Accepted Payment Methods

We accept most insurance plans, HSA/FSA, and flexible cash-pay options to fit your needs.

Referrals & Affiliates

We proudly collaborate with trusted specialists and local partners to support comprehensive care.

Patient Testimonials

"I have nothing but positive things to say about Preston and GPC! From working with him on shared patients to trusting him with the care of my family members, he is thorough and very competent. I love that he takes his time with each patient and looks for real solutions instead of pushing medicine. I highly recommend him!

- Laura M. Sanders

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"Guardian Primary Care is a fantastic addition to Cape Girardeau! The staff is professional, friendly, and truly cares about their patients. The clinic has a welcoming atmosphere, and the option for both in-person and tele-health appointments makes scheduling so convenient. It’s refreshing to see a healthcare provider that puts such an emphasis on patient comfort and accessibility. Highly recommend for anyone looking for reliable and compassionate primary care!"

- Sho R.

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"Preston is very thorough with his patients. He answers any and all questions that one may have. Highly recommend to anyone looking for a PCP that is easy to get in with and doesn’t break the bank!"

- Mercedes Stiltner

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"I felt very respected and valued here as a patient."

- Brea Baker

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"I’m incredibly grateful for the care of Preston Holifield! He goes above and beyond as a patient advocate, always putting his people first. He serves with kindness and excellence, ensuring every patient receives the best care possible. Despite my tight schedule, he found a way to fit me in, addressed all my needs, and even followed up to make sure everything was going as it should. I highly recommend him—he’s the Chick-fil-A of primary care!"

- Jessica S.

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"Love the practice. Extremely friendly and professional. Really takes the time to listen to their patients and very easy to work with when finding new solutions."

- Jared Mungle

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"Guardian has been a pleasant experience. Preston is very personable and professional. He actually listens and cares about your needs and doesn't feel like he trying to push you through like some places"

- Jeremy Franklin

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